Maternal Immunization with a Single-Cycle Herpes Simplex Virus (HSV) Candidate Vaccine, ΔgD-2, Protects Neonatal Mice from Lethal Viral Challenge
نویسندگان
چکیده
944. Perinatal Case Fatality Rate Related to Congenital Zika Syndrome in Brazil: a Cross-Sectional Study Igor Thiago Queiroz, MD, PhD; Jessika Thais Da Silva Maia, MS; Gleysson Rosa, RN, MD; Tatyana Vidal Mendes, RN; S. Jayne Alves Vidal, RN; Maria Goretti Lins, MD; Marcelo Rodrigues Zacarkim, MD, MS; David Aronoff, MD, FIDSA; A. Desiree Labeaud, MD, MS; Nilson N. Mendes Neto, MS; Universidade Potiguar, Natal, Brazil; Universidade Potiguar, Natal – RN, Brazil; Harvard Medical School, Boston, Massachusetts; Secretaria Municipal de Saude, Cajazeiras-PB, cajazeiras-PB, Brazil; SESAP – Rio Grande do Norte, Natal, Brazil; Hospital Infantil Varela Santiago, Natal, Brazil; Vanderbilt University School of Medicine, Division of Infectious Diseases, Nashville, Tennessee; Pediatric Infectious Diseases, Stanford University, Stanford, California; Extension Center, University of California, Davis, Davis, California
منابع مشابه
HSV-2 ΔgD elicits FcγR-effector antibodies that protect against clinical isolates.
A single-cycle herpes simplex virus (HSV) deleted in glycoprotein D (ΔgD-2) elicited high titer HSV-specific antibodies (Abs) that (i) were rapidly transported into the vaginal mucosa; (ii) elicited antibody-dependent cell-mediated cytotoxicity but little neutralization; (iii) provided complete protection against lethal intravaginal challenge; and (iv) prevented establishment of latency in mice...
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